Company Summary:

Metaphore Biotechnologies, Inc. is a privately held biotechnology company building the next generation of biological therapeutics. Inspired by nature, our mission is to transform patient lives by unlocking the power of biological therapeutics with a new mimic-discovery platform.

Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.  Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.

Position Summary

Metaphore Bio is actively seeking a talented and highly motivated Associate Scientist/ Scientist I to join our dynamic Next-Generation Sequencing (NGS) team at our lab in Cambridge, MA. The successful candidate will be instrumental in scaling the throughput and rigor of Metaphore’s NGS workflows, while conducting cutting-edge research and contributing to the development of groundbreaking laboratory techniques and applications. The role involves proficiency in NGS support protocols, including NGS library prep, DNA/RNA isolation, qPCR, sample quality control techniques, and various other molecular biology techniques

Responsibilities

• Collaborate in the development of an innovative platform for cellular and molecular analysis by establishing robust protocols for NGS techniques.
• Actively participate in the planning and design of new experiments.
• Execute experiments, analyze raw data, create QC reports, and document results adhering to project timelines.
• Help establish the NGS team as a central resource for the broader research organization to leverage for sequencing needs.
• Assist in developing and implementing Standard Operating Procedures (SOPs).
• Perform and optimize various protocols for nucleic acid extraction from multiple sample types.
• Operate and optimize the use of single-cell microfluidics equipment.
• Prepare NGS libraries, conduct QC, and run Illumina, PacBio and Nanopore sequencers.
• Maintain lab equipment and independently troubleshoot arising issues.
• Keep accurate and detailed records in line with standard laboratory procedures, study protocols, and regulatory compliance.

Qualifications

• BA or MS with at least 6+ years of practical (wet lab) experience in molecular biology techniques. Industry experience preferred.
• Willingness to acquire new research techniques and approaches.
• Self-directed, highly motivated, and a team-oriented individual with a proven ability to multitask.
• Excellent communication skills to interact effectively with colleagues and staff across various scientific disciplines and align efforts in line with company objectives.
• Proficient in developing, preparing, and implementing laboratory Standard Operating Procedures (SOPs).
• Previous experience constructing NGS libraries and operating NGS instruments is highly desirable.
• Prior experience in bioinformatics, with a thorough understanding of Linux and familiarity with Python scripting and statistical programming using R is preferable.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.